Recombinant Human PI3K (p110 alpha/p85 alpha) (N-His tag)
Catalog No : IGX-RP986
291.09€
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| Product name | Recombinant Human PI3K (p110 alpha/p85 alpha) (N-His tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP986 | ||
| Supplier’s Catalog No | IGX-RP986 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 111 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | p110α: PIK3CA, MGC142161, MGC142163, p110-alpha p85α: PIK3R1, GRB1, p85-ALPHA | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM sodium, pHosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110a catalytic subunit (PIK3CA) is frequently mutated or amplified in a variety of cancers including ovarian and colon and this protein is one of the PI3K mutants . PIK3CA gene copy number is increased in over 30% of ovarian cancers and this leads to increased PI3-kinase activity. Furthermore, the activity of p110a is essential for vascular development and inactivation of p110a leads to severe defects in angiogenic sprouting and vascular remodeling . | ||
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