Recombinant Human PI3K (p110 beta/p85 alpha) (N-His tag)
Catalog No : IGX-RP987
291.09€
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| Product name | Recombinant Human PI3K (p110 beta/p85 alpha) (N-His tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP987 | ||
| Supplier’s Catalog No | IGX-RP987 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 111 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | p110α: PIK3CB, PI3K, PIK3C1, PI3Kbeta, MGC133043, p110-BETA, DKFZp779K1237 p85α: PIK3R1, GRB1, p85-ALPHA | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | The PI3K comprises of a 110 kDa catalytic subunit and a 85 kDa regulatory subunit. A number of isoforms of the 110 kDa catalytic subunit and the 85 kDa regulatory subunit exist in cells. The p110ß catalytic subunit (PIK3CB) plays a role in regulating the formation and stability of alpha-2B-beta-3 integrin adhesion bonds, which are necessary for shear force-induced platelet activation . In animal model of prostate tumor formation induced by the tumor suppressor PTEN loss, ablation of p110ß impedes tumorigenesis with a concomitant diminution of AKT phosphorylation . | ||
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