Recombinant Human PI4K2A (N-GST tag)
Catalog No : IGX-RP991
366.40€
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| Product name | Recombinant Human PI4K2A (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP991 | ||
| Supplier’s Catalog No | IGX-RP991 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 79 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | DKFZp761G1923; PI4KII; PIK42A; RP11-548K23.6 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | PI4K2A or phosphatidylinositol 4-kinase type 2 alpha is involved in the formation of phosphatidylinositolpolyphosphates (PtdInsPs) which are centrally involved in many biologic processes ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4K2A phosphorylates PtdIns at the D-4 position which is an essential step in the biosynthesis of PtdInsPs. PI4K2A is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation. PI4K2A generates PtdIns4P-rich domains within the Golgi which regulate targeting of clathrin adaptor AP-1 complexes . PI4K2A is also required for Wnt to regulate LRP6 phosphorylation . | ||
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