Recombinant Human PIP5K1C (N-GST tag)
Catalog No : IGX-RP1003
366.40€
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| Product name | Recombinant Human PIP5K1C (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP1003 | ||
| Supplier’s Catalog No | IGX-RP1003 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 120 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | KIAA0589; LCCS3; PIP5K-GAMMA; PIP5Kgamma; PIPKIg_v4 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | PIP5K1C or phosphatidylinositol-4-phosphate 5-kinase 1 gamma phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. PIP5K1C is found at synapses and has been found to play roles in endocytosis and cell migration. PIP5K1C directly associates with ß-catenin and increases ß-catenin activity downstream of growth factor stimulation . PIP5K1C expression and kinase activity enhance ß-catenin phosphorylation on residues that promote nuclear importation and transcriptional activity. PIP5K1C deficiency impairs neutrophil recruitment as a result of defect in adhesion. PIP5K1C regulated the adhesion through facilitating RhoA GTPase and integrin activation by chemoattractants . | ||
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