Recombinant Human PKAc alpha (N-GST tag)

Catalog No : IGX-RP1004
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Product name Recombinant Human PKAc alpha (N-GST tag)
Catalog No IGX-RP1004
Supplier’s Catalog No IGX-RP1004
Supplier ImuGeX
Source antigen Insect cells
Reactivity Human
Cross reactivity
Applications
Molecular weight 69
Storage -70°C
Other names PKAa; cAPKa; MGC48865; MGC102831
Grade Highly Purified
Purity 70% - 90%
Form 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Reactivity life 6 months
Note For reserch purpose only
Purity 70% - 90%
Description The catalytic subunit C-alpha of PKA (PKAca) is a member of the Ser/Thr protein kinase family and has been assigned to chromosome region 19p13.1 . Null mutation in PKAca leads to early postnatal lethality in the majority of C-alpha knockout mice. Surprisingly, a small percentage of C-alpha knockout mice, although runted, survived to adulthood. In these animals, compensatory increases in C-beta levels occurred in brain whereas many tissues, including skeletal muscle, heart, and sperm, contained less than 10% of the normal PKA activity .