Recombinant Human PLK4 (N-GST tag)
Catalog No : IGX-RP1026
366.40€
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| Product name | Recombinant Human PLK4 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP1026 | ||
| Supplier’s Catalog No | IGX-RP1026 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 140 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | SAK, STK18 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | PLK4 or polo-like kinase 4 is a member of the polo family of serine/threonine protein kinases which localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. The overexpression of PLK4 triggered the simultaneous formation of multiple procentrioles around each preexisting centriole which resulting in centriole amplification and thus, Plk4-induced centriole biogenesis in human cells .The reduced Plk4 gene dosage increases the probability of mitotic errors and cancer development . | ||
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