Recombinant Human RET (N-GST tag)
Catalog No : IGX-RP1034
366.40€
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| Product name | Recombinant Human RET (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP1034 | ||
| Supplier’s Catalog No | IGX-RP1034 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 74 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | PTC, MTC1, HSCR1, MEN2A, MEN2B, RET51, CDHF12, RET-ELE1 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | RET gene codes for a transmembrane tyrosine kinase which is a subunit of a multimeric complex that acts as a receptor for four structurally related molecules: GDNF, neurturin, artemin and persephin . Germline mutations of RET cause a dominantly inherited dysgenesis of the enteric nervous system known as Hirschsprung's disease. RET is constitutively activated by point mutations in hereditary medullary thyroid carcinomas (MTCs). Several single nucleotide polymorphisms of the RET gene have been described. Multiple endocrine neoplasia type 2A (MEN 2A) have been reported to be associated with two mutations of the protooncogene RET . | ||
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