Recombinant Human SIK3 (N-GST tag)
Catalog No : IGX-RP1056
366.40€
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| Product name | Recombinant Human SIK3 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP1056 | ||
| Supplier’s Catalog No | IGX-RP1056 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 62 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | QSK; SIK-3; L19; FLJ12240; KIAA0999 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | Â SIK3 (QSK) is a serine/threonine-protein kinase, belongs to QIK subfamily. The phosphorylation of SIK3 by LKB1 through the 14-3-3 binding enhances its catalytic activity and leads its localization to punctate structures within the cytoplasm . Overexpression of SIK3 promotes G1/S cell cycle progression with ovarian cancer . There are two sites (H331L and A1103V) were mutated at significant frequency in breast cancer (3). SIK3 is a novel tumor-associated antigen (TAA). | ||
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