Recombinant Human SLK (N-GST tag)
Catalog No : IGX-RP1057
366.40€
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| Product name | Recombinant Human SLK (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP1057 | ||
| Supplier’s Catalog No | IGX-RP1057 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 180 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | LOSK, STK2, se20-9, KIAA0204, MGC133067, bA16H23.1 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | SLK or LOSK is a Ste20-like protein kinase that associates with microtubule and centrosome. Inhibition of SLK activity by dominant-negative mutant or RNAi leads to unfocused microtubule arrangement indicating that SLK is needed for microtubule organization and for the proper localization of Golgi complex . Expression of v-Src can down-regulate SLK activity through the involvement of CK2 which can directly phosphorylate and inhibit SLK activity whereas inhibition of CK2 in v-Src-transformed cells results in normal SLK activity . CK2 and SLK can be co-localized in fibroblasts spreading on fibronectin-coated substrates. | ||
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