Recombinant Human TAK1-TAB1 (N-GST tag)
Catalog No : IGX-RP1075
366.40€
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| Product name | Recombinant Human TAK1-TAB1 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP1075 | ||
| Supplier’s Catalog No | IGX-RP1075 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 74 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | TAK1: MAP3K7, TGF1a; TAB1: MAP3K7IP1, 3'-Tab1, MGC57664 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | TAK1 is a serine/threonine protein kinase that mediates signaling by TGFß and morphogenetic protein (BMP) . In response to IL-1, TAK1 forms a kinase complex with TAB1 and this complex is required for the activation of nuclear factor kappa B (Nf?B). TAK1 can also activate MAPK8/JNK and MAP2K4/MKK4 and thus play a role in the cell response to environmental stress. Tak1 is essential for thymocyte development and activation and deletion of TAK1 prevents maturation of single-positive thymocytes displaying CD4 or CD8 . Thymocytes lacking TAK1 fail to activate Nf?B and JNK and are prone to apoptosis upon stimulation. | ||
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