Recombinant Human ULK1 (N-GST tag)
Catalog No : IGX-RP1099
408.24€
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| Product name | Recombinant Human ULK1 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP1099 | ||
| Supplier’s Catalog No | IGX-RP1099 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 125 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | ATG1, UNC51, Unc51.1, FLJ38455 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation. The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein. Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR . ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy . Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein. ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner. | ||
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