Recombinant Human WNK2 (N-GST tag)
Catalog No : IGX-RP1105
366.40€
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| Product name | Recombinant Human WNK2 (N-GST tag) | ||
|---|---|---|---|
| Catalog No | IGX-RP1105 | ||
| Supplier’s Catalog No | IGX-RP1105 | ||
| Supplier | ImuGeX | ||
| Source antigen | Insect cells | ||
| Reactivity | Human | ||
| Cross reactivity | |||
| Applications | |||
| Molecular weight | 100 | ||
| Storage | -70°C | ||
|---|---|---|---|
| Other names | KIAA1760; NY-CO-43; P/OKcl.13; PRKWNK2; SDCCAG43 | ||
| Grade | Highly Purified | ||
| Purity | 70% - 90% | ||
| Form | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. | ||
| Reactivity life | 6 months | ||
| Note | For reserch purpose only | ||
| Purity | 70% - 90% | ||
| Description | WNK2 is a serine/threonine kinase of the WNK (with no lysine (K)) protein kinase subfamily that also include WNK1, 3 and 4. The WNK kinases feature a cysteine residue in place of a lysine residue conserved in subdomain II of most kinases. WNK2 is predominantly expressed in brain, heart muscle, small intestine, and colon. As a tumor suppressor, WNK2 is involved in the modulation of growth factor-induced cancer cell proliferation through the MEK1/ERK1/2 pathway. WNK2 expression was found down-regulated epigenetically by promoter methylation in human gliomas. | ||
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