Recombinant Human WNK2 (N-GST tag)

Catalog No : IGX-RP1105
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Product name Recombinant Human WNK2 (N-GST tag)
Catalog No IGX-RP1105
Supplier’s Catalog No IGX-RP1105
Supplier ImuGeX
Source antigen Insect cells
Reactivity Human
Cross reactivity
Applications
Molecular weight 100
Storage -70°C
Other names KIAA1760; NY-CO-43; P/OKcl.13; PRKWNK2; SDCCAG43
Grade Highly Purified
Purity 70% - 90%
Form 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Reactivity life 6 months
Note For reserch purpose only
Purity 70% - 90%
Description WNK2 is a serine/threonine kinase of the WNK (with no lysine (K)) protein kinase subfamily that also include WNK1, 3 and 4. The WNK kinases feature a cysteine residue in place of a lysine residue conserved in subdomain II of most kinases. WNK2 is predominantly expressed in brain, heart muscle, small intestine, and colon. As a tumor suppressor, WNK2 is involved in the modulation of growth factor-induced cancer cell proliferation through the MEK1/ERK1/2 pathway. WNK2 expression was found down-regulated epigenetically by promoter methylation in human gliomas.