Recombinant Rat TXK (N-GST tag)

Catalog No : IGX-RP1137
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Product name Recombinant Rat TXK (N-GST tag)
Catalog No IGX-RP1137
Supplier’s Catalog No IGX-RP1137
Supplier ImuGeX
Source antigen Insect cells
Reactivity Rat
Cross reactivity
Applications
Molecular weight 64
Storage -70°C
Other names RLK; TKL; BTKL; PTK4; PSCTK5
Grade Highly Purified
Purity 70% - 90%
Form 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Reactivity life 6 months
Note For reserch purpose only
Purity 70% - 90%
Description TXK or RLK is a member of the TEC family of non-receptor tyrosine kinases. TXK is expressed in T-cells and is an important component of signaling pathways downstream of lymphocyte antigen receptor. TXK is phosphorylated in response to T-cell receptor stimulation and can be activated by phosphorylation by Src family kinases. However, TXK is phosphorylated independent of PI-3K activity . Excessive TXK protein expression is seen in patients with Behcet's disease. Over production of TXK leads to increased Th1 cell function that is involved in the pathogenesis of Behcet’s disease .