Imugex

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Categories: Peptides & Proteins / Proteins

Storage			-70°C
Other names			Monocyte Chemotactic Protein-1, MCP-1, CCL2, MCAF, C-C motif chemokine 2, HC11, Monocyte chemotactic and activating factor, Monocyte secretory protein JE, Small-inducible cytokine A2, MCP1, SCYA2<br/>Recombinant Human Monocyte Chemoattractant Protein-1 (CCL2)
Grade			Highly Purified
Purity			>95% as determined by SDS-PAGE
Form			MCP-1 was lyophilized from PBS pH 7.4.
Reactivity life			6 months
Note			For reserch purpose only
Purity			>95% as determined by SDS-PAGE
Description			MCP-1 belongs to the family of chemotactic cytokines. MCP-1 is expressed by monocytes, vascular endothelial cells, smooth muscle cells, glomerular mesangial cell, and osteoblastic cells. MCP-1 has been shown to exhibit biological activities other than chemotaxis. It can induce the proliferation and activation of killer cells known as CHAK. Elevated levels of MCP-1 are observed in atherosclerotic plaques that are rich in macrophages. The factor activates the tumoricidal activity of monocytes and macrophages in vivo. It regulates the expression of cell surface antigens (CD11c, CD11b) and the expression of cytokines (IL-1, IL-6). MCP-1 is a potent activator of human basophils, inducing degranulation and the release of histamines. In basophils activated by IL-3, IL-5 or GM-CSF MCP-1 enhances the synthesis of leukotriene C4.