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Categories: Diagnostics / Diagnostics

Product name			C-MET gene detection probe, C-MET/CEP7 CE-IVD
Catalog No			FP-046
Supplier’s Catalog No			FP-046
Supplier			Wuhan Healthcare Biotech
Source antigen			C-MET
Reactivity			C-MET, for diagnosis and subtyping of brain and neural cancer.
Cross reactivity			None
Applications			FISH (Fluorescence In Situ Hybridization) for diagnosis of human Lymphomas
Molecular weight			N/A

Storage			-20°C
Other names
Grade			Molecular diagnostic grade
Purity			N/A
Form			Liquid
Reactivity life			12 months when stored properly according to instructions
Note			For Professional In Vitro diagnostics
Description			C-MET gene maps to chromosome 7q31.2 and encodes a transmembrane tyrosine kinase receptor. The ligand of MET is hepatocyte growth factor (HGF), which is secreted by mesenchymal cells. The combination of HGF and c-MET can promote cell proliferation, migration, differentiation and morphological changes. C-MET can amplify in a variety of tumors (ovarian cancer，breast cancer, lung cancer, thyroid cancer, stomach cancer, pancreatic cancer, colorectal cancer) and is an independent poor prognostic factor. In non-small cell lung cancer, C-MET gene amplification is closely associated with poor prognosis and EGFR-TKIs resistance (seen in 11-22% of cases). C-MET gene amplification is one of the targets of crizotinib. In patients with MET gene amplification, the tumor shrinks significantly after a period of treatment.