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Categories: Peptides & Proteins / Proteins

Product name			Recombinant Human Interleukin-1 receptor antagonist protein (IL-1RN) Active
Catalog No			IGX-RP2045-1MG
Supplier’s Catalog No			IGX-RP2045-1MG
Supplier			ImuGeX
Source antigen			Recombinant, expressed in E.Coli, 26-177 Amino Acids
Reactivity			Mouse
Cross reactivity			Mouse
Applications			Functional studies, Bioassays or User optimised
Molecular weight			17.2 KDa

Storage			Store at -20℃/-80℃.
Other names			IL-1RN, IRAP, ICIL-1RA, IL1 inhibitor, Anakinra
Grade			Highly Purified
Purity			>95% determined by SDS-PAGE and HPLC, Endotoxin Level: <1.0 EU/µg as determined by LAL method.
Form			Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reactivity life			12 months, when stored accoring to instructions.
Note			For reserch purpose only, not for In Vivo use or as therapeutics.
Purity			>95% determined by SDS-PAGE and HPLC, Endotoxin Level: <1.0 EU/µg as determined by LAL method.
Description			Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure. Sequence: RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV NLEEKIDVVP IEPHALFLGI HGGKMCLSCV KSGDETRLQL EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE. Tag info:Tag-Free. Biological Activity: Biologically Fully Active when compared to standard. The ED50 as determined by inhibiting IL-1α- dependent proliferation of murine D10S cells is less than 40 ng/ml, corresponding to a specific activity of ＞ 2.5 × 104 IU/mg in the presence of 50 pg/ml rHuIL-1α.