Thiocolchicoside (BRN 0072205, NSC 147755, Coltramyl, 10-thio-Colchicoside, 2-Demethoxy-2-glucosidoxythiocolchicine)

Catalog No : USB-021740
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Product name Thiocolchicoside (BRN 0072205, NSC 147755, Coltramyl, 10-thio-Colchicoside, 2-Demethoxy-2-glucosidoxythiocolchicine)
Catalog No USB-021740
Supplier’s Catalog No 21740
Supplier US Biologicals
Source antigen Synthetic
Reactivity
Cross reactivity
Applications
Molecular weight 563.62
Storage 4°C
Other names
Grade
Purity
Form Yellow solid
Reactivity life 12 months
Note For reserch purpose only
Description Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties. Shows strong epileptogenic and convulsant activity. Anticancer compound through inhibition of NF-kappaB and NF-kappaB-regulated gene products Apoptosis inducer. Suppressed osteoclastogenesis induced by RANKL and tumor cells via the NF-kappaB signaling pathway. Therapeutic option for the management of bone metastatic disease. Form: Yellow solid Melting Point: 190-198°C Solubility: Water Storage and Stability: Short-term Storage: +4°C Long-term Storage: -20°C Stable for at least 2 years after receipt when stored at -20°C.