Anti-Acetyl-Histone H2B (K120) Antibody

Catalog No : IGX-40109

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Description Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Other names Histone H2B type 1-C/E/F/G/I, Histone H2B.1 A, Histone H2B.a, H2B/a, Histone H2B.g, H2B/g, Histone H2B.h, H2B/h, Histone H2B.k, H2B/k, Histone H2B.l, H2B/l, HIST1H2BC, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI, H2BFL, H2BFH, H2BFG, H2BFA, H2BFK
Cellular localization Nucleus, Chromosome
Research area Epigenetics & Nuclear Signaling
Note This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID P62807
Product name Anti-Acetyl-Histone H2B (K120) Antibody
Catalog No IGX-40109
Supplier’s Catalog No IGX-40109
Supplier ImuGeX
Host species Rabbit
Species reactivity Human
Applications ELISA, ICC, IF, ChIP
Recommended dilutions ICC: 1:1-1:10, IF: 1:1-1:10
Molecular weight N/A
Conjugate Unconjugated
Immunogen Peptide sequence around site of Acetyl-Lys (120) derived from Human Histone H2B type 1-C/E/F/G/I
Specificity Acetyl-HIST1H2BC (K120) antibody detects endogenous level of Acetyl-HIST1H2BC (K120) protein
Storage Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity.
Clonality Polyclonal
Isotype IgG
Clone ID N/A
Concentration Concentration can vary between different batches.
Storage buffer Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol.
Formulation Liquid
Purification This antibody is immunogen affinity purified.
Handling This product contains Proclin as preservative, please take appropriate care when handling this product.
Reactivity life 12 months when stored properly according to instructions (provided antibody remains sterile).