Anti-PTPN22 Antibody
Catalog No : IGX-40222
262.00€
188.00€
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| Description | Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PMID:16461343, PMID:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PMID:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PMID:16461343). Dephosphorylates the immune system activator SKAP2 (PMID:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PMID:23871208). Promotes host antiviral responses mediated by type 1 interferon . Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PMID:23991106). | ||
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| Other names | Tyrosine-protein phosphatase non-receptor type 22, EC 3.1.3.48, Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, LyP, PEST-domain phosphatase, PEP, PTPN22, PTPN8 | ||
| Cellular localization | Cytoplasm | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9Y2R2 | ||
| Product name | Anti-PTPN22 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40222 | ||
| Supplier’s Catalog No | IGX-40222 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:200-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Tyrosine-protein phosphatase non-receptor type 22 protein (1-179AA) | ||
| Specificity | PTPN22 antibody detects endogenous level of PTPN22 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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