Anti-CYP2U1 Antibody

Catalog No : IGX-40279

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Description A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PMID:14660610, PMID:24563460). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PMID:14660610, PMID:24563460). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PMID:14660610, PMID:24563460). May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PMID:24563460).
Other names Cytochrome P450 2U1, EC, CYP2U1
Cellular localization Mitochondrion Inner Membrane, Multi-Pass Membrane, Endoplasmic Reticulum Membrane, Multi-Pass Membrane, Microsome Membrane
Research area Metabolism, Cardiovascular
Note This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID Q7Z449
Product name Anti-CYP2U1 Antibody
Catalog No IGX-40279
Supplier’s Catalog No IGX-40279
Supplier ImuGeX
Host species Rabbit
Species reactivity Human
Applications ELISA, IF
Recommended dilutions IF: 1:50-1:200
Molecular weight N/A
Conjugate Unconjugated
Immunogen Recombinant Human Cytochrome P450 2U1 protein (363-496AA)
Specificity CYP2U1 antibody detects endogenous level of CYP2U1 protein
Storage Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity.
Clonality Polyclonal
Isotype IgG
Clone ID N/A
Concentration 1 mg/mL
Storage buffer Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol.
Formulation Liquid
Purification This antibody is immunogen affinity purified.
Handling This product contains Proclin as preservative, please take appropriate care when handling this product.
Reactivity life 12 months when stored properly according to instructions (provided antibody remains sterile).