Anti-CYP2U1 Antibody
Catalog No : IGX-40279
262.00€
188.00€
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| Description | A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates (PMID:14660610, PMID:24563460). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PMID:14660610, PMID:24563460). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes (PMID:14660610, PMID:24563460). May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin (PMID:24563460). | ||
|---|---|---|---|
| Other names | Cytochrome P450 2U1, EC 1.14.14.1, CYP2U1 | ||
| Cellular localization | Mitochondrion Inner Membrane, Multi-Pass Membrane, Endoplasmic Reticulum Membrane, Multi-Pass Membrane, Microsome Membrane | ||
| Research area | Metabolism, Cardiovascular | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q7Z449 | ||
| Product name | Anti-CYP2U1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40279 | ||
| Supplier’s Catalog No | IGX-40279 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Cytochrome P450 2U1 protein (363-496AA) | ||
| Specificity | CYP2U1 antibody detects endogenous level of CYP2U1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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