Anti-ZNRF3 Antibody
Catalog No : IGX-40321
262.00€
188.00€
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| Description | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone (PMID:22575959). Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification . | ||
|---|---|---|---|
| Other names | E3 ubiquitin-protein ligase ZNRF3, EC 2.3.2.27, RING finger protein 203, RING-type E3 ubiquitin transferase ZNRF3, Zinc/RING finger protein 3, ZNRF3, KIAA1133 RNF203 | ||
| Cellular localization | Membrane, Single-Pass Type I Membrane | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9ULT6 | ||
| Product name | Anti-ZNRF3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40321 | ||
| Supplier’s Catalog No | IGX-40321 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human E3 ubiquitin-protein ligase ZNRF3 protein (56-219AA) | ||
| Specificity | ZNRF3 antibody detects endogenous level of ZNRF3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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