Anti-FBXL2 Antibody

Catalog No : IGX-40322
262.00€
188.00€

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Description Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin. Through CCND2 and CCND3 degradation induces cell-cycle arrest in G0 (PMID:22020328, PMID:22323446). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (PMID:23604317). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant .
Other names F-box/LRR-repeat protein 2, F-box and leucine-rich repeat protein 2, F-box protein FBL2/FBL3, FBXL2, FBL2 FBL3
Cellular localization Membrane, Lipid-Anchor
Research area Epigenetics & Nuclear Signaling
Note This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID Q9UKC9
Product name Anti-FBXL2 Antibody
Catalog No IGX-40322
Supplier’s Catalog No IGX-40322
Supplier ImuGeX
Host species Rabbit
Species reactivity Human
Applications ELISA, IF
Recommended dilutions IF: 1:50-1:200
Molecular weight N/A
Conjugate Unconjugated
Immunogen Recombinant Human F-box/LRR-repeat protein 2 protein (1-423AA)
Specificity FBXL2 antibody detects endogenous level of FBXL2 protein
Storage Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity.
Clonality Polyclonal
Isotype IgG
Clone ID N/A
Concentration 1 mg/mL
Storage buffer Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol.
Formulation Liquid
Purification This antibody is immunogen affinity purified.
Handling This product contains Proclin as preservative, please take appropriate care when handling this product.
Reactivity life 12 months when stored properly according to instructions (provided antibody remains sterile).