Anti-DGKZ Antibody
Catalog No : IGX-40428
262.00€
188.00€
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| Description | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PMID:9159104, PMID:15544348, PMID:18004883, PMID:19744926, PMID:22108654, PMID:22627129, PMID:23949095). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PMID:9159104, PMID:15544348, PMID:18004883, PMID:19744926, PMID:22108654, PMID:22627129, PMID:23949095). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species (PMID:9159104, PMID:19744926, PMID:22108654). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (PMID:15544348, PMID:19744926, PMID:22627129). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol . By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (PMID:15157668). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane . | ||
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| Other names | Diacylglycerol kinase zeta, DAG kinase zeta, EC 2.7.1.107, Diglyceride kinase zeta, DGK-zeta, DGKZ, DAGK6 | ||
| Cellular localization | Nucleus, Membrane, Cytosol, Lamellipodium | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q13574 | ||
| Product name | Anti-DGKZ Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40428 | ||
| Supplier’s Catalog No | IGX-40428 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Diacylglycerol kinase zeta protein (11-152AA) | ||
| Specificity | DGKZ antibody detects endogenous level of DGKZ protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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