Anti-RB1CC1 Antibody
Catalog No : IGX-40440
262.00€
188.00€
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| Description | Involved in autophagy (PMID:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PMID:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy . Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis . Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PMID:10769033, PMID:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 . Functions as a DNA-binding transcription factor (PMID:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PMID:14533007). Plays a crucial role in muscular differentiation (PMID:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis . | ||
|---|---|---|---|
| Other names | RB1-inducible coiled-coil protein 1, FAK family kinase-interacting protein of 200 kDa, FIP200, RB1CC1, KIAA0203 RBICC | ||
| Cellular localization | Lysosome, Nucleus, Cytosol, Cytoplasm, Preautophagosomal Structure | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q8TDY2 | ||
| Product name | Anti-RB1CC1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40440 | ||
| Supplier’s Catalog No | IGX-40440 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human RB1-inducible coiled-coil protein 1 protein (1544-1594AA) | ||
| Specificity | RB1CC1 antibody detects endogenous level of RB1CC1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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