Anti-ULK1 Antibody
Catalog No : IGX-40455
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Serine/threonine-protein kinase involved in autophagy in response to starvation (PMID:18936157, PMID:21460634, PMID:21795849, PMID:25040165). Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes (PMID:18936157, PMID:21460634, PMID:21795849, PMID:25040165). Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR (PMID:21795849). Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity (PMID:21460634). May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences (PMID:18936157). Plays a role early in neuronal differentiation and is required for granule cell axon formation (PMID:11146101). May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PMID:25040165). Phosphorylates FLCN, promoting autophagy (PMID:25126726). | ||
|---|---|---|---|
| Other names | Serine/threonine-protein kinase ULK1, EC 2.7.11.1, Autophagy-related protein 1 homolog, ATG1, hATG1, Unc-51-like kinase 1, ULK1, KIAA0722 | ||
| Cellular localization | Cytosol, Preautophagosomal Structure | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O75385 | ||
| Product name | Anti-ULK1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40455 | ||
| Supplier’s Catalog No | IGX-40455 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Serine/threonine-protein kinase ULK1 protein (602-715AA) | ||
| Specificity | ULK1 antibody detects endogenous level of ULK1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved