Anti-TNPO3 Antibody
Catalog No : IGX-40459
262.00€
188.00€
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| Description | Importin, which transports target proteins into the nucleus (PMID:10366588, PMID:10713112, PMID:11517331, PMID:12628928, PMID:24449914). Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains (PMID:10366588, PMID:10713112, PMID:11517331, PMID:12628928, PMID:24449914). Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation (PMID:30916345, PMID:31465518). The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively (PMID:23878195, PMID:24449914). Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus (PMID:23878195, PMID:24449914).8 Publications (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus (PMID:18722123, PMID:21901095, PMID:22398280, PMID:29329553). Required for a nuclear maturation step of HIV-1 prior to integration (PMID:21901095, PMID:22398280). | ||
|---|---|---|---|
| Other names | Transportin-3, Importin-12, Imp12, Transportin-SR, TRN-SR, TNPO3, IPO12 | ||
| Cellular localization | Nucleus Envelope, Cytoplasm | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9Y5L0 | ||
| Product name | Anti-TNPO3 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40459 | ||
| Supplier’s Catalog No | IGX-40459 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Transportin-3 protein (382-458AA) | ||
| Specificity | TNPO3 antibody detects endogenous level of TNPO3 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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