Anti-KDM6B Antibody
Catalog No : IGX-40488
262.00€
188.00€
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| Description | Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PMID:17825402, PMID:17851529, PMID:17713478, PMID:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PMID:17825402, PMID:17851529, PMID:17713478, PMID:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PMID:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PMID:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex . | ||
|---|---|---|---|
| Other names | Lysine-specific demethylase 6B, EC 1.14.11.-, JmjC domain-containing protein 3, Jumonji domain-containing protein 3, Lysine demethylase 6B, KDM6B, JMJD3 KIAA0346 | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O15054 | ||
| Product name | Anti-KDM6B Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40488 | ||
| Supplier’s Catalog No | IGX-40488 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Lysine-specific demethylase 6B protein (1530-1682AA) | ||
| Specificity | KDM6B antibody detects endogenous level of KDM6B protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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