Anti-KMT2B Antibody
Catalog No : IGX-40728
262.00€
188.00€
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| Description | Histone methyltransferase that methylates 'Lys-4' of histone H3 (PMID:17707229). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PMID:17707229). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (PMID:17707229). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development . Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation . | ||
|---|---|---|---|
| Other names | Histone-lysine N-methyltransferase 2B, Lysine N-methyltransferase 2B, EC 2.1.1.43, Myeloid/lymphoid or mixed-lineage leukemia protein 4, Trithorax homolog 2, WW domain-binding protein 7, WBP-7, KMT2B, HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7 | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9UMN6 | ||
| Product name | Anti-KMT2B Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40728 | ||
| Supplier’s Catalog No | IGX-40728 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Histone-lysine N-methyltransferase 2B protein (145-290AA) | ||
| Specificity | KMT2B antibody detects endogenous level of KMT2B protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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