Anti-INPP5F Antibody
Catalog No : IGX-40729
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PMID:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PMID:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PMID:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PMID:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress . May play a role as negative regulator of axon regeneration after central nervous system injuries . | ||
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| Other names | Phosphatidylinositide phosphatase SAC2, EC 3.1.3.25, Inositol polyphosphate 5-phosphatase F, Sac domain-containing inositol phosphatase 2, Sac domain-containing phosphoinositide 4-phosphatase 2, hSAC2, INPP5F, KIAA0966 SAC2 | ||
| Cellular localization | Early Endosome, Recycling Endosome, Clathrin-Coated Pit | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9Y2H2 | ||
| Product name | Anti-INPP5F Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40729 | ||
| Supplier’s Catalog No | IGX-40729 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Peptide sequence from Human Phosphatidylinositide phosphatase SAC2 protein (187-204AA) | ||
| Specificity | INPP5F antibody detects endogenous level of INPP5F protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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