Anti-BIRC5 Antibody
Catalog No : IGX-40789
262.00€
188.00€
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| Description | Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PMID:9859993, PMID:21364656, PMID:20627126, PMID:25778398, PMID:28218735). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PMID:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PMID:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PMID:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PMID:18591255). May counteract a default induction of apoptosis in G2/M phase (PMID:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PMID:20826784). May play a role in neoplasia (PMID:10626797). Inhibitor of CASP3 and CASP7 (PMID:21536684). Essential for the maintenance of mitochondrial integrity and function (PMID:25778398). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PMID:12773388, PMID:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PMID:10626797). | ||
|---|---|---|---|
| Other names | Baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, BIRC5, API4 IAP4 | ||
| Cellular localization | Spindle, Nucleus, Cytoplasm, Chromosome, Centromere, Kinetochore, Midbody | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | O15392 | ||
| Product name | Anti-BIRC5 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40789 | ||
| Supplier’s Catalog No | IGX-40789 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IF | ||
| Recommended dilutions | IF: 1:50-1:500 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Baculoviral IAP repeat-containing protein 5 protein (1-130AA) | ||
| Specificity | BIRC5 antibody detects endogenous level of BIRC5 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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