Anti-Bcl2 Antibody
Catalog No : IGX-40800
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PMID:17418785). | ||
|---|---|---|---|
| Other names | Apoptosis regulator Bcl-2, Bcl2, Bcl-2 | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Single-Pass Membrane, Mitochondrion Outer Membrane, Nucleus Membrane | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P10417 | ||
| Product name | Anti-Bcl2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-40800 | ||
| Supplier’s Catalog No | IGX-40800 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Mouse | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:10-1:100 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Mouse Apoptosis regulator Bcl-2 protein (5-205AA) | ||
| Specificity | Bcl2 antibody detects endogenous level of Bcl2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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