Anti-PLA2G16 Antibody
Catalog No : IGX-41052
262.00€
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| Description | Exhibits both phospholipase A1/2 and acyltransferase activities (PMID:19615464, PMID:19047760, PMID:22825852, PMID:22605381, PMID:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PMID:19615464, PMID:19047760, PMID:22825852, PMID:22605381, PMID:22923616). For most substrates, PLA1 activity is much higher than PLA2 activity (PMID:19615464). Shows O-acyltransferase activity,catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PMID:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PMID:19615464, PMID:19047760, PMID:22825852, PMID:22605381). Exhibits high N-acyltransferase activity and low phospholipase A1/2 activity (PMID:22825852). (Microbial infection) Acts as a host factor for picornaviruses: required during early infection to promote viral genome release into the cytoplasm (PMID:28077878). May act as a cellular sensor of membrane damage at sites of virus entry, which relocalizes to sites of membrane rupture upon virus unfection (PMID:28077878). Facilitates safe passage of the RNA away from LGALS8, enabling viral genome translation by host ribosome (PMID:28077878). May also be involved in initiating pore formation, increasing pore size or in maintaining pores for genome delivery (PMID:28077878). The lipid-modifying enzyme activity is required for this process (PMID:28077878). | ||
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| Other names | HRAS-like suppressor 3, HRSL3, EC 3.1.1.32, EC 3.1.1.4, Adipose-specific phospholipase A2, AdPLA, Group XVI phospholipase A1/A2, H-rev 107 protein homolog, H-REV107, HREV107-1, HRAS-like suppressor 1, HREV107-3, Renal carcinoma antigen NY-REN-65, PLA2G16, HRASLS3 HREV107 | ||
| Cellular localization | Membrane, Single-Pass Membrane, Peroxisome Membrane, Cytoplasm, Perinuclear Region | ||
| Research area | Cancer | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P53816 | ||
| Product name | Anti-PLA2G16 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41052 | ||
| Supplier’s Catalog No | IGX-41052 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human HRAS-like suppressor 3 protein (1-132AA) | ||
| Specificity | PLA2G16 antibody detects endogenous level of PLA2G16 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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