Anti-RAB5A Antibody
Catalog No : IGX-41069
262.00€
188.00€
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| Description | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PMID:10818110, PMID:14617813, PMID:16410077, PMID:15378032). Contributes to the regulation of filopodia extension (PMID:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PMID:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 . | ||
|---|---|---|---|
| Other names | Ras-related protein Rab-5A, RAB5A, RAB5 | ||
| Cellular localization | Cytosol, Early Endosome Membrane, Lipid-Anchor, Endosome Membrane, Membrane, Lipid-Anchor, , Melanosome, Cytoplasmic Vesicle, Ruffle, Membrane, Phagosome Membrane | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P20339 | ||
| Product name | Anti-RAB5A Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41069 | ||
| Supplier’s Catalog No | IGX-41069 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Ras-related protein Rab-5A protein (1-215AA) | ||
| Specificity | RAB5A antibody detects endogenous level of RAB5A protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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