Anti-PPP1R16B Antibody
Catalog No : IGX-41619
262.00€
188.00€
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| Description | Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PMID:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PMID:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity . Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage . Involved in the regulation of endothelial cell filopodia extension . May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PMID:16263087, PMID:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PMID:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PMID:16263087). Involved in the dephosphorylation of EEF1A1 (PMID:26497934). | ||
|---|---|---|---|
| Other names | Protein phosphatase 1 regulatory inhibitor subunit 16B, Ankyrin repeat domain-containing protein 4, CAAX box protein TIMAP, TGF-beta-inhibited membrane-associated protein, hTIMAP, PPP1R16B, ANKRD4 KIAA0823 | ||
| Cellular localization | Membrane, Lipid-Anchor, Nucleus, Cell Projection | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q96T49 | ||
| Product name | Anti-PPP1R16B Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41619 | ||
| Supplier’s Catalog No | IGX-41619 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Protein phosphatase 1 regulatory inhibitor subunit 16B protein (101-400AA) | ||
| Specificity | PPP1R16B antibody detects endogenous level of PPP1R16B protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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