Anti-MACROD1 Antibody
Catalog No : IGX-41712
262.00€
188.00€
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| Description | Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PMID:23474714, PMID:23474712). Inactive towards proteins bearing poly-ADP-ribose (PMID:23474714, PMID:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PMID:21257746). Plays a role in estrogen signaling (PMID:17893710, PMID:17914104, PMID:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PMID:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PMID:17893710, PMID:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PMID:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PMID:17893710). Enhances ESR1-mediated transcription activity (PMID:17914104). | ||
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| Other names | O-acetyl-ADP-ribose deacetylase MACROD1, EC 3.2.2.-, EC 3.5.1.-, MACRO domain-containing protein 1, Protein LRP16, [Protein ADP-ribosylglutamate] hydrolase, MACROD1, LRP16 | ||
| Cellular localization | Nucleus | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9BQ69 | ||
| Product name | Anti-MACROD1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41712 | ||
| Supplier’s Catalog No | IGX-41712 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human O-acetyl-ADP-ribose deacetylase MACROD1 protein (83-325AA) | ||
| Specificity | MACROD1 antibody detects endogenous level of MACROD1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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