Anti-CCDC134 Antibody
Catalog No : IGX-41734
262.00€
188.00€
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| Description | In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PMID:25125657). Enhances cytotoxic anti-tumor activity of CD8+ T cells (PMID:25125657). May inhibit ERK and JNK signaling activity (PMID:18087676, PMID:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PMID:23070808). In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. | ||
|---|---|---|---|
| Other names | Coiled-coil domain-containing protein 134, CCDC134 | ||
| Cellular localization | Cytoplasm, Endoplasmic Reticulum, Nucleus, Secreted | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9H6E4 | ||
| Product name | Anti-CCDC134 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41734 | ||
| Supplier’s Catalog No | IGX-41734 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Coiled-coil domain-containing protein 134 protein (23-229AA) | ||
| Specificity | CCDC134 antibody detects endogenous level of CCDC134 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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