Anti-MANF Antibody
Catalog No : IGX-41925
237.00€
175.00€
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| Description | Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (PMID:12794311). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra . Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons . Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death (PMID:18561914, PMID:22637475, PMID:29497057). Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions (PMID:22637475). Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia (PMID:22637475). Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells (PMID:29497057). Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions (PMID:29497057). | ||
|---|---|---|---|
| Other names | Mesencephalic astrocyte-derived neurotrophic factor, Arginine-rich protein, Protein ARMET, MANF, ARMET ARP | ||
| Cellular localization | Endoplasmic Reticulum Lumen, Secreted, Sarcoplasmic Reticulum Lumen | ||
| Research area | Neuroscience | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P55145 | ||
| Product name | Anti-MANF Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41925 | ||
| Supplier’s Catalog No | IGX-41925 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor protein (25-182AA) | ||
| Specificity | MANF antibody detects endogenous level of MANF protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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