Anti-ACTR2 / Actin-related protein 2 homolog Antibody
Catalog No : IGX-41931
237.00€
175.00€
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| Description | ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PMID:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PMID:9000076). Seems to contact the pointed end of the daughter actin filament (PMID:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PMID:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PMID:17220302, PMID:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PMID:29925947). | ||
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| Other names | Actin-related protein 2, Actin-like protein 2, ACTR2, ARP2 | ||
| Cellular localization | Cell Projection, Cytoskeleton, Nucleus | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P61160 | ||
| Product name | Anti-ACTR2 / Actin-related protein 2 homolog Antibody | ||
|---|---|---|---|
| Catalog No | IGX-41931 | ||
| Supplier’s Catalog No | IGX-41931 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Actin-related protein 2 protein (1-160AA) | ||
| Specificity | ACTR2 antibody detects endogenous level of ACTR2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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