Anti-CASP14 / Caspase 14 Antibody
Catalog No : IGX-42012
237.00€
175.00€
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| Description | Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PMID:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin . In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PMID:16854378, PMID:19960512). Involved in processing of prosaposin in the epidermis . May be involved in retinal pigment epithelium cell barrier function (PMID:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PMID:24743736). | ||
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| Other names | Caspase-14, CASP-14, EC 3.4.22.-, [Cleaved into: Caspase-14 subunit p17, mature form, Caspase-14 subunit p10, mature form, Caspase-14 subunit p20, intermediate form, Caspase-14 subunit p8, intermediate form], CASP14 | ||
| Cellular localization | Cytoplasm, Nucleus | ||
| Research area | Cancer, Cell biology, Metabolism | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P31944 | ||
| Product name | Anti-CASP14 / Caspase 14 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42012 | ||
| Supplier’s Catalog No | IGX-42012 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Caspase-14 protein (1-242AA) | ||
| Specificity | CASP14 antibody detects endogenous level of CASP14 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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