Anti-CASP14 / Caspase 14 Antibody

Catalog No : IGX-42012
237.00€
175.00€

Shipping cost plus VAT not included , delivery in 7-14 business days

Description Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PMID:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin . In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PMID:16854378, PMID:19960512). Involved in processing of prosaposin in the epidermis . May be involved in retinal pigment epithelium cell barrier function (PMID:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PMID:24743736).
Other names Caspase-14, CASP-14, EC 3.4.22.-, [Cleaved into: Caspase-14 subunit p17, mature form, Caspase-14 subunit p10, mature form, Caspase-14 subunit p20, intermediate form, Caspase-14 subunit p8, intermediate form], CASP14
Cellular localization Cytoplasm, Nucleus
Research area Cancer, Cell biology, Metabolism
Note This product is for research purpose only, not for use in diagnostics or as therapeutics.
Uniprot ID P31944
Product name Anti-CASP14 / Caspase 14 Antibody
Catalog No IGX-42012
Supplier’s Catalog No IGX-42012
Supplier ImuGeX
Host species Rabbit
Species reactivity Human
Applications ELISA, IHC
Recommended dilutions IHC: 1:20-1:200
Molecular weight N/A
Conjugate Unconjugated
Immunogen Recombinant Human Caspase-14 protein (1-242AA)
Specificity CASP14 antibody detects endogenous level of CASP14 protein
Storage Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity.
Clonality Polyclonal
Isotype IgG
Clone ID N/A
Concentration Concentration can vary between different batches.
Storage buffer Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol.
Formulation Liquid
Purification This antibody is immunogen affinity purified.
Handling This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product.
Reactivity life 12 months when stored properly according to instructions (provided antibody remains sterile).