Anti-DHRS2 Antibody
Catalog No : IGX-42040
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. | ||
|---|---|---|---|
| Other names | Dehydrogenase/reductase SDR family member 2, mitochondrial, EC 1.1.1.-, Dicarbonyl reductase HEP27, Protein D, Short chain dehydrogenase/reductase family 25C member 1, DHRS2, SDR25C1 | ||
| Cellular localization | Mitochondrion Matrix, Nucleus | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q13268 | ||
| Product name | Anti-DHRS2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42040 | ||
| Supplier’s Catalog No | IGX-42040 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Dehydrogenase/reductase SDR family member 2, mitochondrial protein (1-300AA) | ||
| Specificity | DHRS2 antibody detects endogenous level of DHRS2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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