Anti-MTM1 Antibody
Catalog No : IGX-42079
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) (PMID:11001925, PMID:10900271, PMID:12646134, PMID:14722070). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides (PMID:9537414). Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome (PMID:14722070). Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture (PMID:21135508). Plays a role in mitochondrial morphology and positioning (PMID:21135508). Required for skeletal muscle maintenance but not for myogenesis (PMID:21135508). In skeletal muscles, stabilizes MTMR12 protein levels (PMID:23818870). | ||
|---|---|---|---|
| Other names | Myotubularin, Phosphatidylinositol-3,5-bisphosphate 3-phosphatase, EC 3.1.3.95, Phosphatidylinositol-3-phosphate phosphatase, EC 3.1.3.64, MTM1, CG2 | ||
| Cellular localization | Late Endosome, Membrane, Peripheral Membrane, Cytoplasm, Filopodium, Ruffle, Sarcomere | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q13496 | ||
| Product name | Anti-MTM1 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42079 | ||
| Supplier’s Catalog No | IGX-42079 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Myotubularin protein (484-603AA) | ||
| Specificity | MTM1 antibody detects endogenous level of MTM1 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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