Anti-ZBTB48 Antibody
Catalog No : IGX-42754
237.00€
175.00€
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| Description | Telomere-binding protein that acts as a regulator of telomere length (PMID:28500257, PMID:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PMID:28500257, PMID:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PMID:28082411). Also acts as a transcription regulator that binds to promoter regions (PMID:7969177, PMID:24382891, PMID:28500257). Regulates expression of a small subset of genes, including MTFP1 (PMID:28500257). Regulates expression the J and/or S elements in MHC II promoter (PMID:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PMID:24382891). | ||
|---|---|---|---|
| Other names | Telomere zinc finger-associated protein, TZAP, Krueppel-related zinc finger protein 3, hKR3, Zinc finger and BTB domain-containing protein 48, Zinc finger protein 855, ZBTB48, HKR3 TZAP ZNF855 | ||
| Cellular localization | Nucleus, Telomere | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P10074 | ||
| Product name | Anti-ZBTB48 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42754 | ||
| Supplier’s Catalog No | IGX-42754 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Telomere zinc finger-associated protein (1-280AA) | ||
| Specificity | ZBTB48 antibody detects endogenous level of ZBTB48 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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