Anti-DHDDS Antibody
Catalog No : IGX-42769
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (PMID:25066056, PMID:28842490). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (PMID:21572394). | ||
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| Other names | Dehydrodolichyl diphosphate synthase complex subunit DHDDS, EC 2.5.1.87, Cis-isoprenyltransferase, CIT, Cis-IPTase, Epididymis tissue protein Li 189m, DHDDS, HDS | ||
| Cellular localization | Endoplasmic Reticulum Membrane, Peripheral Membrane | ||
| Research area | Metabolism | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q86SQ9 | ||
| Product name | Anti-DHDDS Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42769 | ||
| Supplier’s Catalog No | IGX-42769 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Dehydrodolichyl diphosphate synthase complex subunit DHDDS protein (1-333AA) | ||
| Specificity | DHDDS antibody detects endogenous level of DHDDS protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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