Anti-VPS11 Antibody
Catalog No : IGX-42933
237.00€
175.00€
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| Description | Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PMID:11382755, PMID:23351085, PMID:24554770, PMID:25266290, PMID:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PMID:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PMID:21148287). Involved in the retrograde Shiga toxin transport (PMID:23593995). | ||
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| Other names | Vacuolar protein sorting-associated protein 11 homolog, hVPS11, RING finger protein 108, VPS11, RNF108 | ||
| Cellular localization | Endosome, Late Endosome Membrane, Peripheral Membrane, , Early Endosome, Lysosome, Lysosome Membrane, Cytoplasmic Vesicle, Autophagosome, Clathrin-Coated Vesicle | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9H270 | ||
| Product name | Anti-VPS11 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42933 | ||
| Supplier’s Catalog No | IGX-42933 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Vacuolar protein sorting-associated protein 11 homolog protein (692-941AA) | ||
| Specificity | VPS11 antibody detects endogenous level of VPS11 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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