Anti-CAMSAP2 Antibody
Catalog No : IGX-42983
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PMID:23169647, PMID:24486153, PMID:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PMID:24486153, PMID:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PMID:24486153, PMID:24706919). In addition, it also reduces the velocity of microtubule polymerization (PMID:24486153, PMID:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PMID:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PMID:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PMID:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PMID:28726242). | ||
|---|---|---|---|
| Other names | Calmodulin-regulated spectrin-associated protein 2, Calmodulin-regulated spectrin-associated protein 1-like protein 1, CAMSAP2, CAMSAP1L1 KIAA1078 | ||
| Cellular localization | Golgi Apparatus, Cytoskeleton | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q08AD1 | ||
| Product name | Anti-CAMSAP2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42983 | ||
| Supplier’s Catalog No | IGX-42983 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Calmodulin-regulated spectrin-associated protein 2 protein (1-150AA) | ||
| Specificity | CAMSAP2 antibody detects endogenous level of CAMSAP2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
Product Details
© 2020 Imugex All Rights Reserved