Anti-CORO1C Antibody
Catalog No : IGX-42984
237.00€
175.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PMID:25074804, PMID:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PMID:25074804, PMID:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments . Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PMID:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PMID:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia . Required for normal distribution of mitochondria within cells . Isoform 3: Involved in myogenic differentiation. | ||
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| Other names | Coronin-1C, Coronin-3, hCRNN4, CORO1C, CRN2 CRNN4 | ||
| Cellular localization | Endosome Membrane, Membrane, Peripheral Membrane, , Ruffle Membrane, Cytoskeleton, Lamellipodium, Cell Cortex, Sarcolemma, Sarcomere, Synapse | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9ULV4 | ||
| Product name | Anti-CORO1C Antibody | ||
|---|---|---|---|
| Catalog No | IGX-42984 | ||
| Supplier’s Catalog No | IGX-42984 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Coronin-1C protein (375-474AA) | ||
| Specificity | CORO1C antibody detects endogenous level of CORO1C protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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