Anti-PDE4DIP Antibody
Catalog No : IGX-43070
237.00€
175.00€
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| Description | Functions as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes . Isoform 13: Participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome (PMID:25217626, PMID:27666745, PMID:28814570, PMID:29162697). In complex with AKAP9, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PMID:27666745, PMID:28814570). In complex with AKAP9, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension from the centrosome to the cell periphery, a crucial process for directed cell migration, mitotic spindle orientation and cell-cycle progression (PMID:29162697). | ||
|---|---|---|---|
| Other names | Myomegalin, Cardiomyopathy-associated protein 2, Phosphodiesterase 4D-interacting protein, PDE4DIP, CMYA2 KIAA0454 KIAA0477 MMGL | ||
| Cellular localization | Golgi Apparatus, Cytoskeleton, Centrosome | ||
| Research area | Cell Biology | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q5VU43 | ||
| Product name | Anti-PDE4DIP Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43070 | ||
| Supplier’s Catalog No | IGX-43070 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Myomegalin protein (1-310AA) | ||
| Specificity | PDE4DIP antibody detects endogenous level of PDE4DIP protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
|---|---|---|---|
| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | Concentration can vary between different batches. | ||
| Storage buffer | Phosphate-buffered saline (pH 7.3) containing 0.02% Sodium Azide (NaN3) and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains sodium azide (NaN3) as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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