Anti-TAF6 Antibody
Catalog No : IGX-43166
262.00€
188.00€
Shipping cost plus VAT not included , delivery in 7-14 business days
| Description | TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Isoform 4: Transcriptional regulator which acts primarily as a positive regulator of transcription (PMID:20096117, PMID:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PMID:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PMID:18628956). In contrast, down-regulates transcription of MDM2 (PMID:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PMID:20096117). Can also activate transcription and apoptosis independently of TP53 (PMID:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PMID:29358700). | ||
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| Other names | Transcription initiation factor TFIID subunit 6, RNA polymerase II TBP-associated factor subunit E, Transcription initiation factor TFIID 70 kDa subunit, TAF,II,70, TAFII-70, TAFII70, Transcription initiation factor TFIID 80 kDa subunit, TAF,II,80, TAFII-80, TAFII80, TAF6, TAF2E TAFII70 | ||
| Cellular localization | Nucleus | ||
| Research area | Epigenetics & Nuclear Signaling | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | P49848 | ||
| Product name | Anti-TAF6 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43166 | ||
| Supplier’s Catalog No | IGX-43166 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Transcription initiation factor TFIID subunit 6 protein (627-677AA) | ||
| Specificity | TAF6 antibody detects endogenous level of TAF6 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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