Anti-NMNAT2 Antibody
Catalog No : IGX-43209
262.00€
188.00€
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| Description | Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor . Catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP (PMID:16118205, PMID:17402747). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency (PMID:16118205, PMID:17402747). Cannot use triazofurin monophosphate (TrMP) as substrate (PMID:16118205, PMID:17402747). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+ (PMID:16118205, PMID:17402747). For the pyrophosphorolytic activity prefers NAD+, NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively (PMID:16118205, PMID:17402747). Fails to cleave phosphorylated dinucleotides NADP+, NADPH and NaADP+ (PMID:16118205, PMID:17402747). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons . | ||
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| Other names | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2, NMN/NaMN adenylyltransferase 2, EC 2.7.7.1, EC 2.7.7.18, Nicotinamide mononucleotide adenylyltransferase 2, NMN adenylyltransferase 2, Nicotinate-nucleotide adenylyltransferase 2, NaMN adenylyltransferase 2, NMNAT2, C1orf15 KIAA0479 | ||
| Cellular localization | Golgi Apparatus Membrane, Lipid-Anchor, Cytoplasmic Vesicle Membrane, Cytoplasm, Axon | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9BZQ4 | ||
| Product name | Anti-NMNAT2 Antibody | ||
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| Catalog No | IGX-43209 | ||
| Supplier’s Catalog No | IGX-43209 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 protein (1-153AA) | ||
| Specificity | NMNAT2 antibody detects endogenous level of NMNAT2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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