Anti-GBA2 Antibody
Catalog No : IGX-43213
262.00€
188.00€
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| Description | Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide (PMID:17105727, PMID:30308956). Glucosylceramides are membrane glycosphingolipids that have a wide intracellular distribution . They are the main precursors of more complex glycosphingolipids that play a role in cellular growth, differentiation, adhesion, signaling, cytoskeletal dynamics and membrane properties . Also involved in the transglucosylation of cholesterol, transferring glucose from glucosylceramides, thereby modifying its water solubility and biological properties . Under specific conditions, may catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide . Finally, may also play a role in the metabolism of bile acids (PMID:11489889, PMID:9111029, PMID:17080196). It is able to hydrolyze bile acid 3-O-glucosides but also to produce bile acid-glucose conjugates thanks to a bile acid glucosyl transferase activity (PMID:11489889, PMID:9111029, PMID:17080196). However, the relevance of both activities is unclear in vivo . | ||
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| Other names | Non-lysosomal glucosylceramidase, NLGase, EC 3.2.1.45, Beta-glucocerebrosidase 2, Beta-glucosidase 2, Glucosylceramidase 2, GBA2, KIAA1605 | ||
| Cellular localization | Golgi Apparatus Membrane, Peripheral Membrane, , Endoplasmic Reticulum Membrane | ||
| Research area | Signal Transduction | ||
| Note | This product is for research purpose only, not for use in diagnostics or as therapeutics. | ||
| Uniprot ID | Q9HCG7 | ||
| Product name | Anti-GBA2 Antibody | ||
|---|---|---|---|
| Catalog No | IGX-43213 | ||
| Supplier’s Catalog No | IGX-43213 | ||
| Supplier | ImuGeX | ||
| Host species | Rabbit | ||
| Species reactivity | Human | ||
| Applications | ELISA, IHC | ||
| Recommended dilutions | IHC: 1:20-1:200 | ||
| Molecular weight | N/A | ||
| Conjugate | Unconjugated | ||
| Immunogen | Recombinant Human Non-lysosomal glucosylceramidase protein (656-867AA) | ||
| Specificity | GBA2 antibody detects endogenous level of GBA2 protein | ||
| Storage | Store at +4°C for short term (1 week), for long term aliquote and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles, with each freeze and thaw cycle an antibody can lose half of its binding activity. | ||
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| Clonality | Polyclonal | ||
| Isotype | IgG | ||
| Clone ID | N/A | ||
| Concentration | 1 mg/mL | ||
| Storage buffer | Phosphate-buffered saline (pH 7.4) containing 0.03% Proclin and 50% Glycerol. | ||
| Formulation | Liquid | ||
| Purification | This antibody is immunogen affinity purified. | ||
| Handling | This product contains Proclin as preservative, please take appropriate care when handling this product. | ||
| Reactivity life | 12 months when stored properly according to instructions (provided antibody remains sterile). | ||
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